Is essential tremor a Purkinjopathy? The role of the cerebellar cortex in its pathogenesis.
Identifieur interne : 000948 ( Main/Exploration ); précédent : 000947; suivant : 000949Is essential tremor a Purkinjopathy? The role of the cerebellar cortex in its pathogenesis.
Auteurs : Giuliana Grimaldi [Belgique] ; Mario MantoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- pathology : Cerebellar Cortex, Essential Tremor, Purkinje Cells.
- physiology : Purkinje Cells.
- Humans.
Abstract
Essential tremor (ET) encompasses a group of progressive neurological diseases in which the primary clinical feature is kinetic tremor of the arms. There is accumulating evidence to suggest that the cerebellum is involved in the pathogenesis of ET; the clinical presentation, neurophysiological data, and functional and metabolic abnormalities revealed by neuroimaging studies all point toward the dysregulation of cerebellar circuits. Recent neuropathological findings at postmortem demonstrate that Purkinje neurons, and some brainstem neurons, play an integral role in the pathogenesis of this common neurological disorder. The assessment of Purkinje cell linear density shows that Purkinje density is abnormal in ET brains. Specific efforts need be devoted to understanding the molecular and cellular events occurring in the Purkinje neurons of the cerebellar cortex, which are emerging as being of particular importance in the pathogenesis of ET in a subgroup of patients.
DOI: 10.1002/mds.25645
PubMed: 24114851
Affiliations:
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Le document en format XML
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The role of the cerebellar cortex in its pathogenesis.</title><author><name sortKey="Grimaldi, Giuliana" sort="Grimaldi, Giuliana" uniqKey="Grimaldi G" first="Giuliana" last="Grimaldi">Giuliana Grimaldi</name><affiliation wicri:level="3"><nlm:affiliation>Unité d'Etude du Mouvement, Hôpital Erasme-Université Libre de Bruxelles, Bruxelles, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité d'Etude du Mouvement, Hôpital Erasme-Université Libre de Bruxelles, Bruxelles</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Manto, Mario" sort="Manto, Mario" uniqKey="Manto M" first="Mario" last="Manto">Mario Manto</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellar Cortex (pathology)</term><term>Essential Tremor (pathology)</term><term>Humans</term><term>Purkinje Cells (pathology)</term><term>Purkinje Cells (physiology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellar Cortex</term><term>Essential Tremor</term><term>Purkinje Cells</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Purkinje Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Essential tremor (ET) encompasses a group of progressive neurological diseases in which the primary clinical feature is kinetic tremor of the arms. There is accumulating evidence to suggest that the cerebellum is involved in the pathogenesis of ET; the clinical presentation, neurophysiological data, and functional and metabolic abnormalities revealed by neuroimaging studies all point toward the dysregulation of cerebellar circuits. Recent neuropathological findings at postmortem demonstrate that Purkinje neurons, and some brainstem neurons, play an integral role in the pathogenesis of this common neurological disorder. The assessment of Purkinje cell linear density shows that Purkinje density is abnormal in ET brains. Specific efforts need be devoted to understanding the molecular and cellular events occurring in the Purkinje neurons of the cerebellar cortex, which are emerging as being of particular importance in the pathogenesis of ET in a subgroup of patients.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><noCountry><name sortKey="Manto, Mario" sort="Manto, Mario" uniqKey="Manto M" first="Mario" last="Manto">Mario Manto</name></noCountry><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Grimaldi, Giuliana" sort="Grimaldi, Giuliana" uniqKey="Grimaldi G" first="Giuliana" last="Grimaldi">Giuliana Grimaldi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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